Argentina’s second center for quality wine production, Cafayate is a popular tourist destination but still has a tranquil small-town feel. It’s easily reached from Salta via the spectacular Quebrada de Cafayate, and is also the southern terminus of the Valles Calchaquíes route. With a selection of excellent accommodations for every budget, and several wineries to visit in and around town, Cafayate invites laying up for a while to explore the surrounding area. It also has many young artists and craftspeople, so check out the artesanía.

Cafayate is famous for its torrontés, a grape producing aromatic but unexpectedly dry white wine, but the bodegas hereabouts also produce some fine reds from cabernet sauvignon, malbec, and tannat.

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